Acute Myeloid Leukaemia (ALL)
Definition
Proliferation of blast cells of myeloid origin (progenitor of RBC, neutrophil, eosinophil, basophil, megakaryocyte, monocyte, mast cells)
Risk Factors
Epidemiology
Clinical Features
Symptoms
Investigations
Blood: WCC usually raised but can be normal or decreased, blood film (Auer rods diagnostic)
Management
Prognosis
Source
OHCM 9th Ed 2014
Proliferation of blast cells of myeloid origin (progenitor of RBC, neutrophil, eosinophil, basophil, megakaryocyte, monocyte, mast cells)
Risk Factors
- Chemo (eg for lymphoma)
- Radiation
- Down's syndrome
Epidemiology
- Most common acute leukaemia in adults (cf. ALL most common in children)
Clinical Features
Symptoms
- Marrow failure: Anaemia, infections, bleeding
- Infiltration: Lympho/hepato/ splenomegaly, gum hypertrophy
- CNS involvement rare (cf. ALL common)
Investigations
Blood: WCC usually raised but can be normal or decreased, blood film (Auer rods diagnostic)
Management
- Chemo
- Bone marrow transplant
Prognosis
- 2 mo if untreated
- 20% 3 yr survival with rx
Source
OHCM 9th Ed 2014