Myelodysplastic Syndrome
Epidemiology
Increasing trend
Aetiology
Secondary causes
Clinical Features
Weakness, infections, haemorrhage, all due to pancytopaenia
Investigations
Blood: FBC (++MCV) --> 1st sign of MDS
Complication
MPD
AML (10-40%)
Prognosis
Median survival 9-29 mo
Source
Prof Kim Rooney 2014
Dr Ros Malley 2013
Increasing trend
Aetiology
Secondary causes
- Chemotherapy - Lymphoma (ALL), testicular teratoma, breast ca (Risk-benefit)
- Benzenes
- Insecticides/ fungicides
- Virus
Clinical Features
Weakness, infections, haemorrhage, all due to pancytopaenia
Investigations
Blood: FBC (++MCV) --> 1st sign of MDS
Complication
MPD
AML (10-40%)
Prognosis
Median survival 9-29 mo
Source
Prof Kim Rooney 2014
Dr Ros Malley 2013