Assessment of Renal Function
- GFR: N ≈ 125mL/min/1.73m2
- 1.73m2 = body surface area
- Most people are above this, thus eGFR underestimate GFR (risk lies in small sized old females)
- ClCr OVERestimates GFR due proximal tubule secretion of creatinine --> need to normalise to be able to compare
- Determination of drug clearance --> base on absolute measure of renal function
- Cockcroft & Gault equation: CreatClear = (female 0.85) * ((140 - Age) / (SerumCreat)) * (Weight / 72)
- Serum creatinine inaccurate (due altered creatinine generation)
Source
Mr Peter Fowler